Artigo recomendado: Ultrasound-guided Multilevel Paravertebral Blocks and Total Intravenous Anesthesia Improve the Quality of Recovery after Ambulatory Breast Tumor Resection

Faraj W. Abdallah, Pamela J. Morgan, Tulin Cil, Andrew McNaught, Jaime M. Escallon, John L. Semple, Wei Wu, Vincent W. Chan

Anesthesiology 2014; 120:703-13

ABSTRACT

Background: Regional anesthesia improves postoperative analgesia and enhances quality of recovery (QoR) after ambulatory surgery. This randomized, double-blinded, parallel-group, placebo-controlled trial examines the effects of multilevel ultrasound-guided paravertebral blocks (PVBs) and total intravenous anesthesia on QoR after ambulatory breast tumor resection.

Methods: Sixty-six women were randomized to standardized general anesthesia (control group) or PVBs and propofol-based total intravenous anesthesia (PVB group). The PVB group received T1–T5 PVBs with 5 ml of 0.5% ropivacaine per level, whereas the control group received sham subcutaneous injections. Postoperative QoR was designated as the primary outcome. The 29-item ambulatory QoR tool was administered in the preadmission clinic, before discharge, and on postoperative days 2, 4, and 7. Secondary outcomes included block success, pain scores, intra- and postoperative morphine consumption, time to rescue analgesia, incidence of nausea and vomiting, and hospital discharge time.

Results: Data from sixty-four patients were analyzed. The PVB group had higher QoR scores than control group upon discharge (146 vs. 131; P < 0.0001) and on postoperative day 2 (145 vs. 135; P = 0.013); improvements beyond postoperative day 2 lacked statistical significance. None of the PVB group patients required conversion to inhalation gas–based general anesthesia or experienced block-related complications. PVB group patients had improved pain scores on postanesthesia care unit admission and discharge, hospital discharge, and postoperative day 2; their intraoperative morphine consumption, incidence of nausea and vomiting, and discharge time were also reduced.

Conclusion: Combining multilevel PVBs with total intravenous anesthesia provides reliable anesthesia, improves postoperative analgesia, enhances QoR, and expedites discharge compared with inhalational gas- and opioid-based general anesthesia for ambulatory breast tumor resection.

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Artigo recomendado: Current concepts in the understanding of malignant hyperthermia

Tae W. Kim, Henry Rosenberg, Nina Nami

Anesthesiology News - February 2014

Malignant hyperthermia (MH) is a pharmacogenetic disorder triggered by exposure to halogenated volatile anesthetic gases and succinylcholine. The underlying mechanism for this potentially lethal condition involves the unregulated release of calcium from the sarcoplasm reticulum into the myoplasm. The ryanodine receptor protein encoded by the RYR1 gene on chromosome 19q.13.1 forms the calcium channel.

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